- Title
- A multicomponent access to 1,3-thiazine-6-phenylimino-5-carboxylates
- Creator
- Trinh, Trieu N.; McCluskey, Adam
- Relation
- NHMRC|1021156 http://purl.org/au-research/grants/nhmrc/1021156
- Relation
- Tetrahedron Letters Vol. 57, Issue 30, p. 3256-3259
- Publisher Link
- http://dx.doi.org/10.1016/j.tetlet.2016.06.007
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2016
- Description
- The multicomponent reaction of ethyl 3-aminocrotonate (1), substituted phenylisothiocyanates (2a–i) and acetic anhydride (7), afforded facile access to a series of substituted 1,3-thiazine-6-phenylimino-5-carboxylates under mild conditions in 15–65% yields. Limited tolerance for modification of the anhydride moiety was noted with a significant reduction in yield for propionic and trifluoroacetic anhydrides. The use of benzoic anhydride favoured a two-component coupling product.
- Subject
- multicomponent reaction; isothiocyanate; 1,3-Thiazine; anhydride; ethyl 3-aminocrotonate
- Identifier
- http://hdl.handle.net/1959.13/1324554
- Identifier
- uon:25063
- Identifier
- ISSN:0040-4039
- Rights
- © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
- Language
- eng
- Full Text
- Reviewed
- Hits: 6757
- Visitors: 4851
- Downloads: 762
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Author final version | 209 KB | Adobe Acrobat PDF | View Details Download |